González Segundo, Queiro Ruben, Ballina Javier
Departamento de Biología Funcional, IUOPA, Universidad de Oviedo, Oviedo, España.
Reumatol Clin. 2012 Mar;8 Suppl 1:S1-6. doi: 10.1016/j.reuma.2011.12.003. Epub 2012 Jan 28.
Psoriasis and psoriatic arthritis are autoimmune diseases that share common pathogenic mechanisms. The cause and the pathogenesis of these diseases are unknown; however, there is increasing evidence which suggest that cytotoxic CD8T cells, Th1 and Th17 may be involved in the pathogenesis of these diseases. Cytokines produced as the result of Th1 and Th17 responses, such as TNF-α and IL-17, play a key role in the chronic inflammatory response observed in the joints of psoriatic arthritis patients. It is conceivable that unraveling of the pathogenesis of this disease may lead to the development of new therapeutic approaches and may improve the prognosis of patients.
银屑病和银屑病关节炎是具有共同致病机制的自身免疫性疾病。这些疾病的病因和发病机制尚不清楚；然而，越来越多的证据表明，细胞毒性CD8T细胞、Th1和Th17可能参与了这些疾病的发病机制。Th1和Th17反应产生的细胞因子，如TNF-α和IL-17，在银屑病关节炎患者关节中观察到的慢性炎症反应中起关键作用。可以想象，阐明这种疾病的发病机制可能会导致新治疗方法的开发，并可能改善患者的预后。
