INSERM UMRS 975, Centre de Recherche de l'Institut du Cerveau et de Moelle Epinière et Université Pierre et Marie Curie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Neuropsychologia. 2012 Apr;50(5):800-9. doi: 10.1016/j.neuropsychologia.2012.01.014. Epub 2012 Jan 20.
Inhibition of return (IOR) refers to slower reaction times to targets presented at previously stimulated or inspected locations. This phenomenon biases orienting towards novel locations and is functional to an effective exploration of the environment. Patients with right brain damage and left visual neglect explore their environment asymmetrically, with strong difficulties to orient attention to left-sided objects. We show for the first time a dissociation between manual and saccadic IOR in neglect. Our patients demonstrated facilitation, instead of inhibition, for repeated right-sided targets with manual responses, but normal IOR to right-sided targets with saccadic responses. All neglect patients had damage to the supramarginal gyrus in the right parietal lobe, or to its connections with the ipsilateral prefrontal cortex. We concluded that IOR with manual responses relies on fronto-parietal attentional networks in the right hemisphere, whose functioning is typically impaired in neglect patients. Saccadic IOR may instead depend on circuits less likely to be damaged in neglect, such as the retinotectal visual pathway.
返回抑制（IOR）是指对先前被刺激或检查过的位置呈现的目标的反应时间变慢。这种现象会使注意力偏向新的位置，这对于有效探索环境是很有功能性的。右脑损伤和左视觉忽视的患者会以不对称的方式探索他们的环境，很难将注意力集中到左侧的物体上。我们首次在忽视中发现了手动和扫视 IOR 之间的分离。我们的患者在用手动反应重复右侧目标时表现出促进作用，而不是抑制作用，但用扫视反应对右侧目标的 IOR 则正常。所有忽视患者的右侧顶叶的缘上回或其与同侧前额叶皮层的连接都有损伤。我们的结论是，用手动反应的 IOR 依赖于右半球的额顶注意网络，而在忽视患者中，该网络的功能通常会受损。扫视 IOR 可能依赖于在忽视中不太可能受损的回路，例如视网膜-顶盖视觉通路。
