Division of Neuro-Interventional Radiology, University of Washington: Harborview Medical Center (HMC), 925 Ninth Avenue, Box 359736, Seattle, WA 98104, USA.
Curr Osteoporos Rep. 2012 Mar;10(1):42-7. doi: 10.1007/s11914-011-0088-6.
Atypical femoral shaft fractures are associated with the extended usage of nitrogen-containing bisphosphonates as therapy for osteoporosis. For such fractures, the positron emission tomography (PET) procedure, coupled with computerized tomography (CT), provides a potential imaging modality for defining aspects of the pathogenesis, site specificity, and possible prodromal abnormalities prior to fracture. PET-CT may assess the radiokinetic variables K1 (a putative marker for skeletal blood flow) and Ki (a putative marker for skeletal bone formation), and when combined with PET imaging modalities and CT skeletal site localization, may define the site of such radiokinetic findings. Further studies into the clinical usage of PET-CT in patients with atypical femoral shaft fractures are warranted.
非典型股骨骨干骨折与氮杂双膦酸盐的广泛应用有关，这些药物被用于治疗骨质疏松症。对于此类骨折，正电子发射断层扫描（PET）与计算机断层扫描（CT）相结合，为定义发病机制、部位特异性以及骨折前可能出现的前驱异常等方面提供了一种潜在的影像学方法。PET-CT 可评估放射性动力学变量 K1（一种骨骼血流的假定标志物）和 Ki（一种骨骼骨形成的假定标志物），当与 PET 成像方式和 CT 骨骼部位定位相结合时，可确定这些放射性动力学发现的部位。进一步研究 PET-CT 在非典型股骨骨干骨折患者中的临床应用是有必要的。
