Rabagliati B Ricardo, Siri Z Leonardo, Pérez C Carlos M, Labarca L Jaime, Ferrés G Marcela
División de Pediatría, Pontificia Universidad Católica de Chile, Chile.
Rev Chilena Infectol. 2011 Dec;28(6):546-53. Epub 2012 Jan 5.
Pandemic influenza A (H1N1) 2009 raised questions regarding differences with seasonal influenza.
To describe the clinical features of pandemic influenza and compare them to seasonal influenza. PATIENTS Y METHODS: A descriptive study that compared hospitalized adults was done between patients with confirmed pandemic influenza in the Hospital Clínico Universidad Católica in Santiago, Chile, from May to July 2009 and 95 confirmed historic cases of seasonal influenza.
54 patients with pandemic influenza were included, 51.9% were male, age of 52.8 ± 19.5 years old; 79.6% had chronic diseases; 16.7% were immunocompromised patients and 7.4% of pregnant women. 25.9% of the patients acquired the infection during the hospitalization. 31.5% were admitted to intermediate/intensive care units. Pneumonia was diagnosed in 37%, and the mortality rate was 3.7%. The comparison between pandemic and seasonal influenza showed less proportion of patient > 65 years of age (31.5% vs. 68%; p < 0.0001); double number of nosocomial acquisition and more cases of pneumonia and death.
The pandemic influenza infection affected younger people and was related with more nosocomial cases, pneumonia and mortality rates than seasonal influenza.
2009年甲型H1N1流感大流行引发了有关其与季节性流感差异的问题。
描述甲型H1N1流感大流行的临床特征并与季节性流感进行比较。患者与方法：开展一项描述性研究，对智利圣地亚哥天主教大学临床医院2009年5月至7月确诊为甲型H1N1流感大流行的住院成人患者与95例确诊的季节性流感历史病例进行比较。
纳入54例甲型H1N1流感大流行患者，51.9%为男性，年龄52.8±19.5岁；79.6%患有慢性病；16.7%为免疫功能低下患者，7.4%为孕妇。25.9%的患者在住院期间感染。31.5%入住中级/重症监护病房。37%被诊断为肺炎，死亡率为3.7%。甲型H1N1流感大流行与季节性流感的比较显示，65岁以上患者比例较低（31.5%对68%；p<0.0001）；医院获得性感染病例数翻倍，肺炎和死亡病例更多。
甲型H1N1流感大流行感染的是年轻人，与季节性流感相比，医院获得性病例、肺炎和死亡率更高。
