[高颈动脉内膜中层厚度年轻受试者的心血管危险因素]
[Cardiovascular risk factors among young subjects with high carotid intima media thickness].
作者信息
Acevedo Mónica, Krämer Verónica, Tagle Rodrigo, Arnaiz Pilar, Corbalán Ramón, Berríos Ximena, Navarrete Carlos
机构信息
División de Enfermedades Cardiovasculares, Pontificia Universidad Católica de Chile, Santiago, Chile.
出版信息
Rev Med Chil. 2011 Oct;139(10):1322-9. Epub 2012 Jan 3.
BACKGROUND
Cardiovascular risk factor (RF) assessment is essential to prevent and predict cardiovascular disease. The presence of RF at early ages, are determinant for the presence of atherosclerosis later in life.
AIM
To determine the RF profile of young subjects with high carotid intima media thickness (CIMT).
MATERIAL AND METHODS
We studied 689 subjects (50% women, mean age 36±6 years) from Santiago, Chile. We determined body mass index (BMI), waist circumference, blood pressure, fasting serum lipids, blood glucose and C-reactive protein. CIMT was assessed by ultrasound using an automatic border recognition software.
RESULTS
Body mass index, waist circumference, blood pressure and serum lipids were significantly higher among subjects located in the higher CIMT quartile. Also, subjects in the higher quartile of CIMT had a higher prevalence of three or more RF compared with the lower quartile (p = 0.01). Finally, individuals with three or more RF showed three times more risk of being in the higher CIMT quartile, than subjects with no RF (odds ratio = 3.1, p < 0.01).
CONCLUSIONS
There is a negative influence of cardiovascular RF on CIMT among young subjects.
背景
心血管危险因素（RF）评估对于预防和预测心血管疾病至关重要。早年存在RF是日后发生动脉粥样硬化的决定性因素。
目的
确定高颈动脉内膜中层厚度（CIMT）的年轻受试者的RF特征。
材料与方法
我们研究了来自智利圣地亚哥的689名受试者（50%为女性，平均年龄36±6岁）。我们测定了体重指数（BMI）、腰围、血压、空腹血脂、血糖和C反应蛋白。使用自动边界识别软件通过超声评估CIMT。
结果
CIMT处于较高四分位数的受试者的体重指数、腰围、血压和血脂显著更高。此外，CIMT处于较高四分位数的受试者与较低四分位数相比，具有三种或更多RF的患病率更高（p = 0.01）。最后，具有三种或更多RF的个体处于CIMT较高四分位数的风险是无RF受试者的三倍（优势比 = 3.1，p < 0.01）。
结论
心血管RF对年轻受试者的CIMT有负面影响。
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