Gligorijevic Jasmina, Zivkovic Vesna, Djordjevic Biljana, Dimov Irena
Medical Faculty, Department of Pathology, University of Nis, Yugoslavia.
Turk J Gastroenterol. 2011 Dec;22(6):626-30. doi: 10.4318/tjg.2011.0278.
A case of gallbladder malignant melanoma in a 62-year-old woman is reported. The gallbladder, resected for tumor mass seen on ultrasound examination, revealed neoplastic epithelioid cells with dark granules in the cytoplasm. These cells with pigment were positive immunohistochemically for S-100, HMB45 and vimentin. The patient, affected by dysplastic nevus syndrome, had a history of a melanoma in situ in her left upper arm that was excised 11 years ago. This is only the second case reported to date of primary malignant melanoma in dysplastic nevus syndrome.
报告了一例62岁女性胆囊恶性黑色素瘤病例。因超声检查发现肿瘤肿块而切除的胆囊显示，肿瘤上皮样细胞的细胞质中有深色颗粒。这些含色素的细胞免疫组化检测S-100、HMB45和波形蛋白呈阳性。该患者患有发育异常痣综合征，11年前曾切除左上臂原位黑色素瘤。这是迄今为止报道的发育异常痣综合征原发性恶性黑色素瘤的第二例病例。
