t(3;8) 作为多形性腺瘤衍生的肌上皮癌中唯一的染色体异常：一个可能的进展事件。
t(3;8) as the sole chromosomal abnormality in a myoepithelial carcinoma ex pleomorphic adenoma: a putative progression event.
机构信息
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
出版信息
Head Neck. 2013 Jun;35(6):E181-3. doi: 10.1002/hed.22926. Epub 2012 Jan 27.
BACKGROUND
Carcinoma ex pleomorphic adenoma (Ca ex-PA) is defined as a carcinoma arising from a primary (de novo) or recurrent benign pleomorphic adenoma (PA).
METHODS
We present a parotid myoepithelial carcinoma ex pleomorphic adenoma in a 38-year-old man with a t(3;8)(p21;q13) as the only chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY).
RESULTS
The finding of this translocation in a subset of PA and in the present case suggests a critical role for this event in the malignant transformation of PA.
CONCLUSIONS
Collectively, both the cytogenetic and the molecular studies suggest the concept that PA lacking alterations pursue a benign behavior, whereas those with the t(3;8) translocation may progress to carcinoma.
背景
癌肉瘤样多形性腺瘤（Ca ex-PA）定义为一种源自原发性（新发）或复发性良性多形性腺瘤（PA）的癌。
方法
我们通过细胞遗传学和光谱核型分析（SKY）展示了一名 38 岁男性腮腺肌上皮癌肉瘤样多形性腺瘤，其唯一的染色体改变是 t（3；8）（p21；q13）。
结果
该易位在一部分 PA 中以及本病例中的发现表明，该事件在 PA 的恶性转化中起关键作用。
结论
细胞遗传学和分子研究均表明，缺乏改变的 PA 表现为良性行为，而具有 t（3；8）易位的 PA 可能进展为癌。
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