School of Engineering and Materials Science, IRC in Biomedical Materials, Queen Mary University, London, UK.
Biomed Mater. 2012 Feb;7(1):015007. doi: 10.1088/1748-6041/7/1/015007. Epub 2012 Jan 27.
Polyurethanes have been widely used in medicine for coating and packaging implantable and other medical devices. Polyether-urethanes, in particular, have superior mechanical properties and are biocompatible, but in common with other medical materials they are susceptible to microbial film formation. In this study, polyether-urethane was end-capped with silver lactate and silver sulfadiazine functional groups to produce a bacterially resistant polymer without sacrificing the useful mechanical properties of the polyether-polyurethane. The silver ions were covalently incorporated into the polymer during chain extension of the prepolymer. The functionalized polymers were structurally characterized by light scattering, electron microscopy, NMR, FTIR and Raman spectroscopy. Mechanical properties, hydrophilicity, in vitro stability and antibacterial action of polymers were also investigated. Results indicate that both silver salts were successfully incorporated into the polymer structure without significant effect on mechanical properties, whilst conferring acceptable bacterial resistance.
聚氨基甲酸酯已广泛应用于医学领域，用于涂层和包装可植入和其他医疗器械。聚醚型聚氨酯具有优异的机械性能和生物相容性，但与其他医用材料一样，它们容易形成微生物膜。在这项研究中，聚醚型聚氨酯的端基用乳酸银和磺胺嘧啶银官能团封端，以生产出一种具有抗细菌性能的聚合物，而不会牺牲聚醚型聚氨酯的有用机械性能。银离子在预聚物的链延伸过程中被共价结合到聚合物中。功能化聚合物的结构通过光散射、电子显微镜、NMR、FTIR 和拉曼光谱进行了表征。还研究了聚合物的机械性能、亲水性、体外稳定性和抗菌作用。结果表明，两种银盐都成功地结合到聚合物结构中，对机械性能没有显著影响，同时赋予了可接受的抗菌性能。
