Nathanael A Joseph, Oh Tae Hwan
School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Korea.
Polymers (Basel). 2020 Dec 21;12(12):3061. doi: 10.3390/polym12123061.
Biopolymer coatings exhibit outstanding potential in various biomedical applications, due to their flexible functionalization. In this review, we have discussed the latest developments in biopolymer coatings on various substrates and nanoparticles for improved tissue engineering and drug delivery applications, and summarized the latest research advancements. Polymer coatings are used to modify surface properties to satisfy certain requirements or include additional functionalities for different biomedical applications. Additionally, polymer coatings with different inorganic ions may facilitate different functionalities, such as cell proliferation, tissue growth, repair, and delivery of biomolecules, such as growth factors, active molecules, antimicrobial agents, and drugs. This review primarily focuses on specific polymers for coating applications and different polymer coatings for increased functionalization. We aim to provide broad overview of latest developments in the various kind of biopolymer coatings for biomedical applications, in order to highlight the most important results in the literatures, and to offer a potential outline for impending progress and perspective. Some key polymer coatings were discussed in detail. Further, the use of polymer coatings on nanomaterials for biomedical applications has also been discussed, and the latest research results have been reported.
由于其灵活的功能化特性,生物聚合物涂层在各种生物医学应用中展现出卓越的潜力。在本综述中,我们讨论了用于各种基材和纳米颗粒的生物聚合物涂层在改善组织工程和药物递送应用方面的最新进展,并总结了最新的研究成果。聚合物涂层用于改变表面性质以满足特定要求,或为不同的生物医学应用赋予额外功能。此外,含有不同无机离子的聚合物涂层可能会促进不同的功能,如细胞增殖、组织生长、修复以及生物分子(如生长因子、活性分子、抗菌剂和药物)的递送。本综述主要关注用于涂层应用的特定聚合物以及用于增强功能化的不同聚合物涂层。我们旨在全面概述用于生物医学应用的各类生物聚合物涂层的最新进展,以突出文献中最重要的结果,并为即将取得的进展和前景提供潜在的框架。一些关键的聚合物涂层将进行详细讨论。此外,还讨论了聚合物涂层在生物医学应用纳米材料上的应用,并报告了最新的研究成果。