新加坡华人和印度人中呼气酒精消除率和 Widmark 因子与呼气酒精浓度的关系。
Breath alcohol elimination rate and Widmark factor derived from breath alcohol concentration in Chinese and Indians in Singapore.
机构信息
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Clinical Research Centre, Singapore.
出版信息
Alcohol Alcohol. 2012 May-Jun;47(3):261-6. doi: 10.1093/alcalc/ags002. Epub 2012 Jan 27.
AIMS
To determine the breath alcohol elimination rate (AER) and Widmark factor derived from the maximum breath alcohol concentration (r(peak BrAC)) in Chinese and Indians in Singapore, and to evaluate the contribution of genetic and non-genetic factors to variability of AER and r(peak BrAC).
METHODS
A total of 180 subjects ingested a vodka-orange juice mixture, together with a standardized meal and underwent a series of BrAC measurements.
RESULTS
Significant inter-ethnic differences in AER and r(peak BrAC) were observed in females and males, respectively. Alcohol dehydrogenase 1B (ADH1B) and acetaldehyde dehydrogenase (ALDH2) genotypes were identified as significant predictors for AER among males, accounting for 8.5% (P = 0.048) and 23.4% (P < 0.001) of the variance, respectively. ADH1B genotype was identified as a significant predictor for r(peak BrAC) among males, accounting for 17.1% of the variance (P = 0.001). In females, however, none of the genotypes were found to be significant predictors for breath AER, and r(peak BrAC).
CONCLUSION
ALDH2 and/or ADH1B genotypes in males, but not in females, appear to contribute, albeit modestly, to variability in AER and r(peak BrAC). The median AER in Chinese males, Indian males, Chinese females and Indian females is 6.6 μg dl(-1) h(-1) [99% confidence interval (CI), 5.6-7.5 μg dl(-1) h(-1)], 6.2 μg dl(-1) h(-1) (99% CI, 5.5-7.0 μg dl(-1) h(-1)), 8.6 μg dl(-1) h(-1) (99% CI, 7.4-9.7 μg dl(-1) h(-1)) and 7.4 μg dl(-1 )h(-1) (99% CI, 6.2-8.4 μg dl(-1) h(-1)), respectively. The median r(peak BrAC) in Chinese males, Indian males, Chinese females and Indian females is 0.0229 (99% CI, 0.0216-0.0268), 0.0209 (99% CI, 0.0190-0.0237), 0.0214 (99% CI, 0.0185-0.0254) and 0.0199 (99% CI, 0.0187-0.0227), respectively.
目的
确定新加坡华人和印度人中的呼气酒精消除率（AER）和最大呼气酒精浓度（r（peak BrAC））的威德马克因子，并评估遗传和非遗传因素对 AER 和 r（peak BrAC）变异性的贡献。
方法
共有 180 名受试者摄入伏特加-橙汁混合物，同时摄入标准餐，并进行了一系列 BrAC 测量。
结果
女性和男性的 AER 和 r（peak BrAC）均存在显著的种族间差异。在男性中，乙醛脱氢酶 1B（ADH1B）和乙醛脱氢酶（ALDH2）基因型被确定为 AER 的显著预测因子，分别占变异的 8.5%（P=0.048）和 23.4%（P<0.001）。ADH1B 基因型被确定为男性 r（peak BrAC）的显著预测因子，占变异的 17.1%（P=0.001）。然而，在女性中，没有发现任何基因型是呼吸 AER 和 r（peak BrAC）的显著预测因子。
结论
在男性中，ALDH2 和/或 ADH1B 基因型似乎对 AER 和 r（peak BrAC）的变异性有一定贡献，但作用不大。中国男性、印度男性、中国女性和印度女性的中位数 AER 分别为 6.6μg dl（-1）h（-1）[99%置信区间（CI），5.6-7.5μg dl（-1）h（-1）]、6.2μg dl（-1）h（-1）（99%CI，5.5-7.0μg dl（-1）h（-1））、8.6μg dl（-1）h（-1）（99%CI，7.4-9.7μg dl（-1）h（-1））和 7.4μg dl（-1）h（-1）（99%CI，6.2-8.4μg dl（-1）h（-1））。中国男性、印度男性、中国女性和印度女性的中位数 r（peak BrAC）分别为 0.0229（99%CI，0.0216-0.0268）、0.0209（99%CI，0.0190-0.0237）、0.0214（99%CI，0.0185-0.0254）和 0.0199（99%CI，0.0187-0.0227）。
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