Beale K M, Helm L J, Keisling K
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32608.
J Am Vet Med Assoc. 1990 Oct 1;197(7):865-7.
Thyroid function was evaluated in 20 healthy dogs by thyrotropin (TSH) response testing. Two dose regimens were used: 5 IU of TSH given IV and 1 IU of TSH given IV. Blood samples were collected prior to and at 4 and 6 hours after TSH administration. Serum was obtained and analyzed for total 3,5,3'-tri-iodothyronine and thyroxine (T4) concentrations by radioimmunoassay. All dogs were classified as euthyroid on the basis of response to 5 IU of TSH at 4 and 6 hours. The 1-IU dose of TSH failed to induce adequate increase in T4 concentration in 7 dogs at 4 and 6 hours when the criteria for normal response were post-TSH serum concentration T4 greater than or equal to 3.0 micrograms/dl and serum T4 increase by greater than or equal to 100% over baseline serum T4 concentration. One IU of TSH induced increase in serum T4 concentration over baseline; however, the increase was significantly (P less than 0.05) less than that in response to a 5-IU dose at 6 hours after administration of TSH.
通过促甲状腺激素（TSH）反应测试对20只健康犬的甲状腺功能进行了评估。使用了两种给药方案：静脉注射5国际单位促甲状腺激素和静脉注射1国际单位促甲状腺激素。在促甲状腺激素给药前以及给药后4小时和6小时采集血样。获取血清并通过放射免疫测定法分析血清中总3,5,3'-三碘甲状腺原氨酸和甲状腺素（T4）的浓度。根据4小时和6小时对5国际单位促甲状腺激素的反应，所有犬均被分类为甲状腺功能正常。当促甲状腺激素后血清T4浓度标准为大于或等于3.0微克/分升且血清T4较基线血清T4浓度增加大于或等于100%时，1国际单位剂量的促甲状腺激素在4小时和6小时未能使7只犬的T4浓度充分升高。1国际单位促甲状腺激素使血清T4浓度高于基线水平；然而，在促甲状腺激素给药后6小时，该升高幅度显著（P<0.05）低于对5国际单位剂量的反应。
