Tiurenkov I N, Samotrueva M A, Serezhnikova T K
Eksp Klin Farmakol. 2011;74(11):36-42.
The review summarizes available data about the influence of GABA-ergic substances on the immune system functional activity under both normal and pathology conditions. Analysis of information in the literature and publications shows that positive/inhibitory effects of GABA and its derivatives on the immune system depend on the overall background organism condition, as well as on parameters such as the level of antigenic stress. In addition, it is shown that changes in the immune reactivity achieved through the GABA-ergic system are dopamine and serotonin dependent. The immunotropic action of GABA and GABA-ergic substances is evidently determined by activating effect upon the multi-level immunogenesis control system, in particular, the GABA-sensitive receptors of the central nervous system and immunocompetent organs, as well as hypothalamo-pituitary-adrenal complex.
本综述总结了关于γ-氨基丁酸能物质在正常和病理条件下对免疫系统功能活性影响的现有数据。对文献和出版物中的信息分析表明，γ-氨基丁酸及其衍生物对免疫系统的正向/抑制作用取决于机体的整体背景状况，以及诸如抗原应激水平等参数。此外，研究表明，通过γ-氨基丁酸能系统实现的免疫反应性变化依赖于多巴胺和血清素。γ-氨基丁酸和γ-氨基丁酸能物质的免疫调节作用显然是由对多级免疫发生控制系统的激活作用所决定的，特别是中枢神经系统和免疫活性器官的γ-氨基丁酸敏感受体，以及下丘脑-垂体-肾上腺复合体。
