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[儿童大脑皮质畸形的宏观和微观系统化]

[Macro- and microscopic systematization of cerebral cortex malformations in children].

作者信息

Milovanov A P, Milovanova O A

出版信息

Arkh Patol. 2011 Sep-Oct;73(5):23-7.

Abstract

For the first time in pediatric pathologicoanatomic practice the complete systematization of cerebral cortex malformations is represented. Organ, macroscopic forms: microencephaly, macroencephaly, micropolygyria, pachygyria, schizencephaly, porencephaly, lissencephaly. Histic microdysgenesis of cortex: type I includes isolated abnormalities such as radial (IA) and tangential (I B) subtypes of cortical dislamination; type II includes sublocal cortical dislamination with immature dysmorphic neurons (II A) and balloon cells (II B); type III are the combination focal cortical dysplasia with tuberous sclerosis of the hippocampus (III A), tumors (III B) and malformations of vessels, traumatic and hypoxic disorders (III C). Band heterotopias. Subependimal nodular heterotopias. Tuberous sclerosis. Cellular typification of cortical dysplasia: immature neurons and balloon cells.

摘要

在儿科病理解剖实践中,首次呈现了大脑皮质畸形的完整系统化。器官、宏观形态:小头畸形、巨头畸形、多小脑回、巨脑回、脑裂畸形、脑穿通畸形、无脑回畸形。皮质组织学微发育异常:I型包括孤立性异常,如皮质分层的放射状(IA)和切线状(IB)亚型;II型包括伴有未成熟畸形神经元(IIA)和气球样细胞(IIB)的局灶性皮质分层异常;III型是局灶性皮质发育异常与海马结节性硬化(IIIA)、肿瘤(IIIB)以及血管畸形、创伤和缺氧性疾病(IIIC)的组合。带状异位。室管膜下结节性异位。结节性硬化。皮质发育异常的细胞分类:未成熟神经元和气球样细胞。

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