Department of Biochemistry, People's College of Medical Sciences and Research Center, Bhopal, Madhya Pradesh, India.
Arch Physiol Biochem. 2012 Feb;118(1):6-9. doi: 10.3109/13813455.2011.645545.
The aim was to determine adenosine deaminase (ADA) and alkaline phosphatase (ALP) activity in sputum for the diagnosis of pulmonary tuberculosis.
This study comprised of 64 subjects (33 pulmonary tuberculosis and 31 lung cancer). The ADA and ALP activity was measured in sputum and serum.
The mean ADA activity in sputum, serum and mean sputum/serum ADA ratio was 205.20 IU/L, 42.32 IU/L and 4.90 in pulmonary tuberculosis and 127.74 IU/L, 29.90 IU/L and 4.27 in lung cancer subjects respectively. The mean ALP activity in sputum, serum and mean sputum/serum ALP ratio was 461.34 IU/L, 159.24 IU/L and 2.90 in pulmonary tuberculosis and 226.64 IU/L, 119.87 IU/L and 1.99 in lung cancer subjects respectively.
The mean ADA and ALP activity was significantly increased in pulmonary tuberculosis as compared to lung cancer subjects and hence may be a useful tool for the diagnosis of pulmonary tuberculosis.
旨在确定痰中腺苷脱氨酶（ADA）和碱性磷酸酶（ALP）活性，用于诊断肺结核。
本研究共纳入 64 名受试者（33 名肺结核和 31 名肺癌）。测量了痰和血清中的 ADA 和 ALP 活性。
肺结核组痰、血清中 ADA 活性及痰/血清 ADA 比值的平均值分别为 205.20IU/L、42.32IU/L 和 4.90，肺癌组分别为 127.74IU/L、29.90IU/L 和 4.27。肺结核组痰、血清中 ALP 活性及痰/血清 ALP 比值的平均值分别为 461.34IU/L、159.24IU/L 和 2.90，肺癌组分别为 226.64IU/L、119.87IU/L 和 1.99。
与肺癌组相比，肺结核组 ADA 和 ALP 活性显著升高，因此可能是诊断肺结核的有用工具。
