肺结核患者痰液中的腺苷脱氨酶和碱性磷酸酶活性。

Sputum adenosine deaminase and alkaline phosphatase activity in pulmonary tuberculosis.

机构信息

Department of Biochemistry, People's College of Medical Sciences and Research Center, Bhopal, Madhya Pradesh, India.

出版信息

Arch Physiol Biochem. 2012 Feb;118(1):6-9. doi: 10.3109/13813455.2011.645545.

DOI:10.3109/13813455.2011.645545

PMID:22289040

Abstract

OBJECTIVE

The aim was to determine adenosine deaminase (ADA) and alkaline phosphatase (ALP) activity in sputum for the diagnosis of pulmonary tuberculosis.

METHODS

This study comprised of 64 subjects (33 pulmonary tuberculosis and 31 lung cancer). The ADA and ALP activity was measured in sputum and serum.

RESULTS

The mean ADA activity in sputum, serum and mean sputum/serum ADA ratio was 205.20 IU/L, 42.32 IU/L and 4.90 in pulmonary tuberculosis and 127.74 IU/L, 29.90 IU/L and 4.27 in lung cancer subjects respectively. The mean ALP activity in sputum, serum and mean sputum/serum ALP ratio was 461.34 IU/L, 159.24 IU/L and 2.90 in pulmonary tuberculosis and 226.64 IU/L, 119.87 IU/L and 1.99 in lung cancer subjects respectively.

CONCLUSION

The mean ADA and ALP activity was significantly increased in pulmonary tuberculosis as compared to lung cancer subjects and hence may be a useful tool for the diagnosis of pulmonary tuberculosis.

摘要

目的

旨在确定痰中腺苷脱氨酶（ADA）和碱性磷酸酶（ALP）活性，用于诊断肺结核。

方法

本研究共纳入 64 名受试者（33 名肺结核和 31 名肺癌）。测量了痰和血清中的 ADA 和 ALP 活性。

结果

肺结核组痰、血清中 ADA 活性及痰/血清 ADA 比值的平均值分别为 205.20IU/L、42.32IU/L 和 4.90，肺癌组分别为 127.74IU/L、29.90IU/L 和 4.27。肺结核组痰、血清中 ALP 活性及痰/血清 ALP 比值的平均值分别为 461.34IU/L、159.24IU/L 和 2.90，肺癌组分别为 226.64IU/L、119.87IU/L 和 1.99。