Wu J-G, Tang H, Liu Z-J, Ma Z-F, Tang A-L, Zhang X-J, Gao X-R, Ma H
Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
J Int Med Res. 2011;39(6):2158-68. doi: 10.1177/147323001103900612.
This study evaluated the effect of angiotensin (Ang)-(1-7) on vascular remodelling in a rat autologous jugular vein graft model in which rats underwent autologous jugular vein graft transplantation (Ang-[1-7] and control groups) or sham surgery (sham group). The animals received continuous jugular infusion of Ang-(1-7) at 25 μg/kg per h (Ang-[1-7] group) or normal saline (control and sham groups) starting 3 days after surgery. Ang-(1-7) infusion reduced venous graft hyperplasia, vascular remodelling, extracellular signal-regulated kinase 1/2 (ERK1/2) activation, p38 mitogen-activated protein kinase (MAPK) activation and levels of proliferating cell nuclear antigen and α-smooth muscle actin compared with control animals. The vascular tissue Ang II level was higher in Ang-(1-7) and control rats than in sham animals. These findings suggest that Ang-(1-7) acts by inhibiting the activation of ERK1/2 and p38 MAPK in vascular tissue. The use of exogenous Ang-(1-7) could improve the outcome of vein grafting through the attenuation of vascular remodelling.
本研究在大鼠自体颈静脉移植模型中评估了血管紧张素（Ang）-(1-7)对血管重塑的影响，该模型中大鼠接受了自体颈静脉移植（Ang-(1-7)组和对照组）或假手术（假手术组）。术后3天开始，动物接受以25μg/kg每小时的速度持续颈静脉输注Ang-(1-7)（Ang-(1-7)组）或生理盐水（对照组和假手术组）。与对照动物相比，输注Ang-(1-7)可减少静脉移植物增生、血管重塑、细胞外信号调节激酶1/2（ERK1/2）激活、p38丝裂原活化蛋白激酶（MAPK）激活以及增殖细胞核抗原和α-平滑肌肌动蛋白水平。Ang-(1-7)组和对照组大鼠的血管组织血管紧张素II水平高于假手术动物。这些发现表明，Ang-(1-7)通过抑制血管组织中ERK1/2和p38 MAPK的激活发挥作用。使用外源性Ang-(1-7)可通过减轻血管重塑改善静脉移植的效果。
