Imipramine treatment of panic disorder during pregnancy.

Two women with panic disorder who continued to be symptomatic during pregnancy were successfully treated with low doses of imipramine. Plasma drug concentrations were lower than usually required for antidepressant response and remained relatively stable during gestation. Each woman delivered a healthy infant with minimal discomfort from panic symptoms during pregnancy. These cases are illustrative of two women who had a need of and benefited from pharmacotherapy for panic disorder during pregnancy.