Bhatt Girish Chandra, Nandan Devki, Dewan Vivek, Dey Soumya
PGIMER & Associated Dr RML Hospital, New Delhi, India.
Trop Doct. 2012 Jan;42(1):63-4. doi: 10.1258/td.2011.110372.
Although acute glomerulonephritis is a rare complication of Plasmodium falciparum malaria, it has not been reported in connection with Plasmodium vivax. We report a case of complicated P. vivax malaria presenting as acute glomerulonephritis. A three-year-old boy presented with high grade fever, a seven-day history of the progressive swelling of his body and a one-day history of vomiting. An examination revealed hypertension (>95th percentile), pallor and hepatosplenomegaly. Investigations showed a platelet count 80,000/mm(3) with haematuria [20-30 red blood cells/high power field with more than 80% dysmorphic red blood cells]. A peripheral smear showed the presence of trophozoites of P. vivax. The patient was diagnosed as having P. vivax causing acute glomerulonephritis and was treated successfully with antimalarials and enalapril. With the changing epidemiological pattern of malaria, especially in endemic areas, unusual complications such as acute glomerulonephritis may sometimes present in cases of P. vivax malaria.
虽然急性肾小球肾炎是恶性疟原虫疟疾的一种罕见并发症,但间日疟原虫疟疾与之相关的情况尚未见报道。我们报告一例以急性肾小球肾炎为表现的间日疟原虫疟疾并发症病例。一名3岁男孩出现高热、身体进行性肿胀7天及呕吐1天的症状。检查发现高血压(>第95百分位数)、面色苍白及肝脾肿大。检查显示血小板计数80,000/mm³ ,伴有血尿[每高倍视野有20 - 30个红细胞,其中80%以上为异形红细胞]。外周血涂片显示存在间日疟原虫滋养体。该患者被诊断为间日疟原虫引起急性肾小球肾炎,并通过抗疟药和依那普利成功治疗。随着疟疾流行病学模式的变化,尤其是在流行地区,间日疟原虫疟疾病例有时可能会出现急性肾小球肾炎等不寻常并发症。