Pharmacopsychiatry. 2012 Jun;45(4):162-3. doi: 10.1055/s-0031-1297933. Epub 2012 Jan 30.
A 29-year-old depressed, otherwise healthy female patient was treated with agomelatine and duloxetine. She developed subsequent akathisia, which subsided after cessation of agomelatine. As a cause we suggest a pharmacodynamic drug-drug interaction leading to noradrenergic overstimulation. We recommend only gradual dose titration when combining the 2 substances to minimize the risk for side effects.
一位 29 岁的抑郁、其他方面健康的女性患者接受了阿戈美拉汀和度洛西汀的治疗。她随后出现静坐不能，停用阿戈美拉汀后症状缓解。我们认为这是一种药效学的药物相互作用导致去甲肾上腺素过度刺激。我们建议在联合使用这两种药物时，仅逐渐调整剂量，以最大程度地降低副作用的风险。
