Munding J, Tannapfel A
Institut für Pathologie, BG-Universitätsklinikum Bergmannsheil, Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum.
Chirurg. 2012 Mar;83(3):208-14. doi: 10.1007/s00104-011-2175-8.
Klatskin tumors are a distinct subgroup of cholangiocarcinomas which are a surgical challenge due to their special localization. Different localizations do not show great differences concerning histomorphology and precursor lesions. With respect to molecular alterations there are only small differences. Accurate clinical and histomorphological diagnosis is important for therapy and especially the prediction of prognosis as well as standardized processing of the resection specimen if the carcinoma is resectable. Additionally, accurate lymph node dissection is necessary. Concerning molecular markers further investigations are needed to develop individualized therapy regimes.
肝门部胆管癌是胆管癌的一个独特亚组，因其特殊的定位给手术带来挑战。不同的定位在组织形态学和前驱病变方面并无显著差异。在分子改变方面，差异也很小。准确的临床和组织形态学诊断对于治疗，尤其是预后预测以及对可切除癌的切除标本进行标准化处理很重要。此外，准确的淋巴结清扫是必要的。关于分子标志物，还需要进一步研究以制定个体化治疗方案。
