Hakomori S
Biomembrane Institute, Seattle, Washington.
J Biol Chem. 1990 Nov 5;265(31):18713-6.
Glycosphingolipids (GSLs), or their modified catabolites, at the cell surface modulate transmembrane signal transduction by influencing protein kinases associated with growth factor receptors and protein kinase C. On the other hand, the same or different GSLs at the cell surface interact in highly specific fashion with other GSLs or with binding proteins, possibly at the surface of adjacent interacting cells or in the extracellular matrix. The GSL-GSL interaction apparently provides the basis for a specific cell recognition system independent of the fibronectin/integrin or surface lectin systems, occurring earlier during a cell recognition event.
糖鞘脂（GSLs）或其修饰的分解代谢产物在细胞表面通过影响与生长因子受体和蛋白激酶C相关的蛋白激酶来调节跨膜信号转导。另一方面，细胞表面相同或不同的GSLs以高度特异性的方式与其他GSLs或结合蛋白相互作用，可能发生在相邻相互作用细胞的表面或细胞外基质中。GSL-GSL相互作用显然为一种独立于纤连蛋白/整合素或表面凝集素系统的特异性细胞识别系统提供了基础，该系统在细胞识别事件中更早发生。
