Zeller C B, Marchase R B
Department of Cell Biology, University of Alabama, Birmingham 35294.
Am J Physiol. 1992 Jun;262(6 Pt 1):C1341-55. doi: 10.1152/ajpcell.1992.262.6.C1341.
Gangliosides, sialic acid-containing glycosphingolipids, are found in the outer leaflet of the plasma membrane of all vertebrate tissues and species. This report presents a brief introduction to the gangliosides and reviews the chemistry and topography of their biosynthesis. It also presents an overview of the present evidence supporting a physiological significance for the gangliosides in a variety of experimental systems. This includes consideration of their potential roles in development and cell adhesion. In addition, experimental examples in which gangliosides appear to influence signal transduction processes through their interactions with plasma membrane proteins are discussed.
神经节苷脂是含唾液酸的糖鞘脂，存在于所有脊椎动物组织和物种的质膜外小叶中。本报告简要介绍了神经节苷脂，并综述了其生物合成的化学过程和拓扑结构。它还概述了目前支持神经节苷脂在各种实验系统中具有生理意义的证据。这包括考虑它们在发育和细胞黏附中的潜在作用。此外，还讨论了神经节苷脂似乎通过与质膜蛋白相互作用影响信号转导过程的实验实例。
