Laboratory of Psychobiology, FFCLRP, Campus USP, Ribeirao Preto, SP 14049, Brazil.
J Psychopharmacol. 1993 Jan;7(1 Suppl):82-8. doi: 10.1177/026988119300700112.
The effects of ipsapirone and cannabidiol (CBD) on healthy volunteers submitted to a simulated public speaking (SPS) test were compared with those of the anxiolytic benzodiazepine diazepam and placebo. Four independent groups of 10 subjects received, under a double-blind design, placebo or one of the following drugs: CBD (300 mg), diazepam (10 mg) or ipsapirone (5 mg). Subjective anxiety was evaluated through the Visual Analogue Mood Scale (VAMS) and the State-trait Anxiety Inventory (STAI). The VAMS anxiety factor showed that ipsapirone attenuated SPS-induced anxiety while CBD decreased anxiety after the SPS test. Diazepam, on the other hand, was anxiolytic before and after the SPS test, but had no effect on the increase in anxiety induced by the speech test. Only ipsapirone attenuated the increase in systolic blood pressure induced by the test. Significant sedative effects were only observed with diazepam. The results suggest that ipsapirone and CBD have anxiolytic properties in human volunteers submitted to a stressful situation.
将伊沙匹隆和大麻二酚 (CBD) 对接受模拟公开演讲 (SPS) 测试的健康志愿者的影响与抗焦虑苯二氮䓬类药物地西泮和安慰剂进行了比较。在双盲设计下，将 4 组各 10 名受试者分别给予安慰剂或以下药物之一：CBD（300 mg）、地西泮（10 mg）或伊沙匹隆（5 mg）。通过视觉模拟情绪量表 (VAMS) 和状态特质焦虑量表 (STAI) 评估主观焦虑。VAMS 焦虑因子表明，伊沙匹隆减轻了 SPS 引起的焦虑，而 CBD 在 SPS 测试后降低了焦虑。另一方面，地西泮在 SPS 测试前后均具有抗焦虑作用，但对演讲测试引起的焦虑增加没有影响。只有伊沙匹隆减轻了测试引起的收缩压升高。仅观察到地西泮有显著的镇静作用。结果表明，伊沙匹隆和 CBD 对处于应激状态的人类志愿者具有抗焦虑作用。
