Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, Chile.
Rev Med Virol. 2012 Jul;22(4):230-44. doi: 10.1002/rmv.1704. Epub 2012 Jan 31.
Respiratory syncytial virus (RSV) is the leading cause for childhood hospitalization and respiratory distress, being recognized as a major health and economic burden worldwide. RSV can exploit host immunity and cause a strong inflammatory response that leads to lung damage and virus dissemination. Unfortunately, the immune response elicited by RSV normally fails to protect against subsequent exposures to the virus. Despite intense research during the 50 years after the discovery of RSV, scientists are just beginning to understand the mechanisms contributing to pathology and to the inadequate immune response shown by susceptible individuals. Here, we discuss some of the most important advances made in this field that could lead to the development of new prophylactic tools.
呼吸道合胞病毒（RSV）是导致儿童住院和呼吸窘迫的主要原因，被认为是全球范围内的一个主要健康和经济负担。RSV 可以利用宿主的免疫功能，引起强烈的炎症反应，导致肺部损伤和病毒传播。不幸的是，RSV 引起的免疫反应通常不能防止随后再次暴露于该病毒。尽管在 RSV 发现后的 50 年里进行了大量研究，但科学家们才刚刚开始了解导致发病机制和易感个体免疫反应不足的机制。在这里，我们讨论了该领域的一些最重要的进展，这些进展可能会导致新的预防工具的开发。
