Departments of Otolaryngology - Head and Neck Surgery/Surgical Oncology, Princess Margaret Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada.
Head Neck. 2013 Jan;35(1):35-9. doi: 10.1002/hed.22908. Epub 2012 Jan 31.
The purpose of this study was to discuss the appropriate management options for parathyroid carcinomas, which is still a subject of controversy.
A retrospective chart review of 16 patients with parathyroid carcinoma was undertaken to determine the clinical outcome.
All patients were initially treated with surgery, and 11 patients received adjuvant radiotherapy. The 5- and 10-year disease-specific survival rates were 100% and 80%, respectively; the 5- and 10-year disease-free survival rates were 69% and 43%, respectively. The 5- and 10-year locoregional control rates were 69% and 52%, respectively; the 5- and 10-year distant control rates were 89% and 74%, respectively. In this cohort, none of the clinicopathologic parameters could be defined as a predictor.
In patients with parathyroid carcinoma, definition of prognostic factors and the role of adjuvant radiation treatment has still to be elucidated. Nevertheless, angioinvasion and positive resection margins are critical factors regarding disease-free survival in patients with parathyroid carcinomas.
本研究旨在探讨甲状旁腺癌的适当治疗选择，这仍然是一个存在争议的问题。
对 16 例甲状旁腺癌患者进行回顾性图表分析，以确定其临床转归。
所有患者最初均接受手术治疗，11 例患者接受辅助放疗。5 年和 10 年疾病特异性生存率分别为 100%和 80%；5 年和 10 年无病生存率分别为 69%和 43%。5 年和 10 年局部区域控制率分别为 69%和 52%；5 年和 10 年远处控制率分别为 89%和 74%。在本队列中，没有任何临床病理参数可以定义为预测因素。
在甲状旁腺癌患者中，预后因素的定义和辅助放疗的作用仍有待阐明。然而，血管侵犯和阳性切缘是影响甲状旁腺癌患者无病生存率的关键因素。
