Laboratory of Polymer Chemistry,Eindhoven University of Technology, Den Dolech 2, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Macromol Rapid Commun. 2012 Feb 27;33(4):272-86. doi: 10.1002/marc.201100730. Epub 2012 Jan 31.
N-Carboxyanhydride ring-opening polymerization (NCA ROP) is a synthetically straightforward methodology to generate homopolypeptides. Extensive control over the polymerization permits the production of highly monodisperse synthetic polypeptides to a targeted molecular weight in the absence of unfavorable side reactions. Sequential NCA ROP permits the creation of block copolypeptides composed of individual polypeptide blocks boasting different functionalities, secondary structures, and desirable chemical properties. Consequently, a plethora of novel materials have been generated that have found wide-range applicability. This review offers an insight into contemporary synthetic approaches toward NCA ROP before highlighting a number of block copolypeptide architectures generated.
N-羧酸酐开环聚合 (NCA ROP) 是一种合成上简单直接的方法，可用于生成均聚物多肽。聚合反应的广泛控制可在没有不利副反应的情况下，生产出具有目标分子量的高度单分散性合成多肽。顺序 NCA ROP 允许创建由具有不同功能、二级结构和理想化学性质的单个多肽块组成的嵌段共多肽。因此，已经产生了大量的新型材料，这些材料具有广泛的适用性。本综述介绍了 NCA ROP 的当代合成方法，然后重点介绍了几种生成的嵌段共多肽结构。
