Zhang Ying, Xu Qiong, Liu Jing, Li She-chang, Xu Xiu
Department of Child Health Care, Children's Hospital of Fudan University, Shanghai, China.
J Child Neurol. 2012 Aug;27(8):975-81. doi: 10.1177/0883073811430163. Epub 2012 Jan 30.
A subgroup of children diagnosed with autism experience developmental regression featured by a loss of previously acquired abilities. The pathogeny of autistic regression is unknown, although many risk factors likely exist. To better characterize autistic regression and investigate the association between autistic regression and potential influencing factors in Chinese autistic children, we conducted an ambispective study with a cohort of 170 autistic subjects. Analyses by multiple logistic regression showed significant correlations between autistic regression and febrile seizures (OR = 3.53, 95% CI = 1.17-10.65, P = .025), as well as with a family history of neuropsychiatric disorders (OR = 3.62, 95% CI = 1.35-9.71, P = .011). This study suggests that febrile seizures and family history of neuropsychiatric disorders are correlated with autistic regression.
一小部分被诊断为自闭症的儿童经历了发育倒退，其特征是丧失了先前获得的能力。尽管可能存在许多风险因素，但自闭症倒退的病因尚不清楚。为了更好地描述自闭症倒退的特征，并调查中国自闭症儿童中自闭症倒退与潜在影响因素之间的关联，我们对170名自闭症受试者进行了一项双向研究。多因素逻辑回归分析显示，自闭症倒退与热性惊厥（OR = 3.53，95%CI = 1.17 - 10.65，P = .025）以及神经精神疾病家族史（OR = 3.62，95%CI = 1.35 - 9.71，P = .011）之间存在显著相关性。这项研究表明，热性惊厥和神经精神疾病家族史与自闭症倒退相关。
