[芽中渗透自由水的重吸收与血管紧张素类似物与V2受体相互作用能量的比较]
[Comparison of reabsorption of osmotically free water in the bud and energy of interaction of vasotocin analogs with a V2-receptor].
作者信息
Kutina A V, Karavashkina T A, Shakhmatova E I, Gao Ts, Mordvintsev D Iu, Kuz'min D A, Tsetlin V I, Natochin Iu V
出版信息
Izv Akad Nauk Ser Biol. 2011 Nov-Dec(6):717-24.
The calculated values of the binding energy of nonapeptides with receptors in docking with their influence on reabsorption of osmotically free water in a rat bud in vivo were compared. Vasotocin and some its analogs were intramuscularly introduced to non-narcotized rat females of the Wistar line in doses from 0.1 pmol to 0.5 nmol/kg of body weight against the background of peroral water load (50 ml/kg of body weight). A significant correlation between the calculated interaction energy of peptides with V2-receptors and an increase of reabsorption of osmotically free water in the rat bud stimulated by injection of nonapeptides was found. The results evidence that alterations in rat bud in vivo caused by analogs of vasotocin and their interactions with V2-receptors can be accurately simulated.
比较了九肽与受体对接时结合能的计算值及其对大鼠体内肾芽中渗透自由水重吸收的影响。在口服水负荷（50毫升/千克体重）的背景下，将血管加压素及其一些类似物以0.1皮摩尔至0.5纳摩尔/千克体重的剂量肌肉注射给未麻醉的Wistar系雌性大鼠。发现肽与V2受体的计算相互作用能与注射九肽刺激大鼠肾芽中渗透自由水重吸收增加之间存在显著相关性。结果表明，血管加压素类似物引起的大鼠体内肾芽变化及其与V2受体的相互作用可以被准确模拟。
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