Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
FEBS Lett. 2012 Jul 4;586(14):1885-96. doi: 10.1016/j.febslet.2012.01.040. Epub 2012 Jan 27.
Transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) cytokines participate in a multiplicity of ways in the regulation of numerous physiological and pathological processes. Their wide-ranging biological functions are controlled by several mechanisms, including regulation of transcription, complex formation among the signaling receptors (oligomerization) and with co-receptors, binding of the receptors to scaffolding proteins or their targeting to specific membrane domains. Here, we address the generation of TGF-β and BMP receptor homo- and hetero-oligomers and its roles as a mechanism capable of fast regulation of signaling by these crucial cytokines. We examine the available biochemical, biophysical and structural evidence for the ternary structure of these complexes, and the possible roles of homomeric and heteromeric receptor oligomers in signaling.
转化生长因子-β（TGF-β）和骨形态发生蛋白（BMP）细胞因子以多种方式参与众多生理和病理过程的调节。它们广泛的生物学功能受多种机制控制，包括转录调控、信号受体（寡聚化）和共受体之间的复合物形成、受体与支架蛋白结合或靶向特定膜域。在这里，我们研究了 TGF-β和 BMP 受体同型和异型寡聚体的产生及其作为这些关键细胞因子快速调节信号的机制。我们检查了这些复合物的三元结构的现有生化、生物物理和结构证据，以及同型和异型受体寡聚体在信号转导中的可能作用。
