Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA.
Cell Mol Life Sci. 2012 Jul;69(13):2135-46. doi: 10.1007/s00018-012-0917-5.
Following the initial discovery that adipose tissue actively synthesizes and secretes cytokines, obesity-induced inflammation has been implicated in the etiology of a host of disease states related to obesity, including cardiovascular disease and type II diabetes. Interestingly, a growing body of evidence similarly implicates sphingolipids as prime instigators in these same diseases. From the recent discovery that obesity-related inflammatory pathways modulate sphingolipid metabolism comes a novel perspective—sphingolipids may act as the dominant mediators of deleterious events stemming from obesity-induced inflammation. This paradigm may identify sphingolipids as an effective target for future therapeutics aimed at ameliorating diseases associated with chronic inflammation.
在最初发现脂肪组织积极合成和分泌细胞因子之后，肥胖引起的炎症与肥胖相关的许多疾病状态的病因有关，包括心血管疾病和 2 型糖尿病。有趣的是，越来越多的证据同样表明鞘脂类物质是这些疾病的主要启动子。最近的发现表明，与肥胖相关的炎症途径调节鞘脂代谢，从而产生了一种新的观点——鞘脂类物质可能作为肥胖引起的炎症所导致的有害事件的主要介质。这一模式可能将鞘脂类物质确定为未来治疗慢性炎症相关疾病的有效靶点。
