Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N, Zhongshan Road, Shanghai 200062, PR China.
Chem Commun (Camb). 2012 Mar 7;48(20):2636-8. doi: 10.1039/c2cc17836b. Epub 2012 Feb 1.
The first example of Yb(OTf)(3)-catalyzed tandem ring opening/Friedel-Crafts cyclization of oxiranyl and aziridinyl ketones via selective C-C bond cleavage under mild conditions was developed. Isochromanones and isoquinolines are formed in reasonable yields, which often serve as building blocks for complex chemical synthesis.
首次发展了 Yb(OTf)(3)催化的温和条件下通过选择性 C-C 键断裂的环氧和氮杂环丁酮的串联开环/Friedel-Crafts 环化反应。异色满酮和异喹啉以合理的产率生成，它们通常作为复杂化学合成的构建块。
