Higgins Guy A, Breysse Nathalie
BioQuest Innovations Inc., Toronto, Ontario, Canada.
Curr Protoc Pharmacol. 2008 Jun;Chapter 5:Unit5.49. doi: 10.1002/0471141755.ph0549s41.
The 5-choice serial reaction time task (5-CSRTT) is the most widely used test to measure attentional performance in rodents. The basic test design involves training animals to respond to a brief visual stimulus presented unpredictably in one of five locations. Once trained to stable performance levels, the effects of experimental manipulations on response speed and choice accuracy are measured and each are related to attentional performance. Increasingly, the test is also used to examine aspects of response control. Having been adapted from a human task, the test has also been successfully extended to the mouse and primate, thus highlighting its translational value. Increasingly this test is being applied in drug discovery efforts, primarily to identify novel drug treatments for conditions associated with attention deficits.
五选择连续反应时任务（5-CSRTT）是测量啮齿动物注意力表现最广泛使用的测试。基本测试设计包括训练动物对在五个位置之一不可预测地呈现的短暂视觉刺激做出反应。一旦训练到稳定的表现水平，就测量实验操作对反应速度和选择准确性的影响，并且将每一项都与注意力表现相关联。该测试越来越多地还用于检查反应控制的各个方面。该测试改编自一项人类任务，也已成功扩展到小鼠和灵长类动物，从而突出了其转化价值。该测试越来越多地应用于药物发现工作中，主要用于识别与注意力缺陷相关病症的新型药物治疗方法。
