Higgins Guy A, Silenieks Leo B
InterVivoSolutions Inc, Toronto, Ontario, Canada.
Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
Curr Protoc Pharmacol. 2017 Sep 11;78:5.49.1-5.49.34. doi: 10.1002/cpph.27.
The 5-choice serial reaction time task (5-CSRTT) is employed extensively to measure attention in rodents. The assay involves animals trained to respond to a brief, unpredictable visual stimulus presented in one of five locations. The effects of experimental manipulations on response speed and choice accuracy are measured, and each related to attentional performance. The 5-CSRTT is also used to measure motor impulsivity. Adapted from a human task, the 5-CSRTT can be employed with rodents or primates, highlighting its translational value. Another strength of this procedure is its adaptability to task modification. An example is the 5-choice continuous performance task, which has both target and non-target trial types. Overall, the 5-CSRTT has proven to be valuable for drug discovery efforts aimed at identifying new agents for the treatment of central nervous system disorders and for further understanding the neurobiological processes of attention and impulsivity. Its flexibility offers considerable scope to the experimenter, and in this respect the task continues to evolve. © 2017 by John Wiley & Sons, Inc.
五选择连续反应时任务（5-CSRTT）被广泛用于测量啮齿动物的注意力。该实验要求动物学会对在五个位置之一出现的短暂、不可预测的视觉刺激做出反应。测量实验操作对反应速度和选择准确性的影响，并将其与注意力表现相关联。5-CSRTT还用于测量运动冲动性。改编自一项人类任务，5-CSRTT可用于啮齿动物或灵长类动物，凸显了其转化价值。该程序的另一个优点是它对任务修改的适应性。例如，五选择连续执行任务，它既有目标试验类型，也有非目标试验类型。总体而言，5-CSRTT已被证明对于旨在识别治疗中枢神经系统疾病新药物的药物研发工作以及进一步理解注意力和冲动性的神经生物学过程具有重要价值。其灵活性为实验者提供了相当大的空间，在这方面该任务仍在不断发展。© 2017 约翰威立父子出版公司
