Moskowitz H, Chen D
Southern California Research Institute, Los Angeles.
J Clin Psychopharmacol. 1990 Aug;10(4 Suppl):20S-23S.
Thirty noninsomniac healthy adult men were enrolled in a multicenter pilot study to evaluate the sensitivity of psychomotor and cognitive tasks and subjective evaluation of performance and mood after treatment with flurazepam (Dalmane) 45 mg (larger than the recommended prescribing dose of 15-30 mg). This pilot study was also used to standardize testing procedures. The subjects were given either flurazepam or placebo at 72-hour intervals in a double-blind Latin square crossover design. Choice reaction time, but not simple reaction time, was drug sensitive. Divided attention and vigilance tasks were also sensitive to drug effects. Of the two cognitive tasks tested, addition was impaired by drug, but reading comprehension was not. Subjective evaluations of performance and mood states indicate that these are useful measures, but responses on the Hopkins Symptom Checklist were not influenced.
30名无失眠症状的健康成年男性参与了一项多中心试点研究，以评估在服用45毫克氟西泮（氟安定）（高于15 - 30毫克的推荐处方剂量）后，精神运动和认知任务的敏感性以及对表现和情绪的主观评估。该试点研究还用于规范测试程序。受试者按照双盲拉丁方交叉设计，每隔72小时服用一次氟西泮或安慰剂。选择反应时间对药物敏感，而简单反应时间则不然。分散注意力和警觉性任务对药物作用也很敏感。在测试的两项认知任务中，加法运算受药物影响，而阅读理解则未受影响。对表现和情绪状态的主观评估表明，这些是有用的测量方法，但霍普金斯症状清单上的反应未受影响。
