Younus J, Ahmed A R
Department of Pathology, Boston University School of Medicine, MA.
J Am Acad Dermatol. 1990 Oct;23(4 Pt 1):720-3. doi: 10.1016/0190-9622(90)70280-u.
In patients with autoimmune diseases malignancy is observed more frequently than in an age-matched control group. In strains of mice susceptible to autoimmune diseases, the incidence of lymphoreticular malignancies is increased. Although viruses have not been directly implicated in their pathogenesis or etiology, there are suggestions that slow viruses may be involved. Viruses have been found to be important in the development of lymphomas. Hence in genetically susceptible animals, viruses can initiate the autoimmune process. Prolonged stimulation of the autoimmune process or a prolonged state of immunodeficiency could trigger or activate genes or their products, which could result in the development of malignancy.
自身免疫性疾病患者中，恶性肿瘤的发生率高于年龄匹配的对照组。在易患自身免疫性疾病的小鼠品系中，淋巴网状恶性肿瘤的发生率增加。虽然病毒尚未直接涉及其发病机制或病因，但有迹象表明慢病毒可能参与其中。已发现病毒在淋巴瘤的发生发展中起重要作用。因此，在基因易感动物中，病毒可引发自身免疫过程。自身免疫过程的长期刺激或免疫缺陷的长期状态可能触发或激活基因或其产物，从而导致恶性肿瘤的发生。
