I-BMIPP 延迟闪烁显像与心绞痛患者的相关性——一项初步研究。

Relevance of I-BMIPP delayed scintigraphic imaging for patients with angina pectoris - a pilot study.

机构信息

Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.

出版信息

Arch Med Sci. 2011 Jun;7(3):428-32. doi: 10.5114/aoms.2011.23407. Epub 2011 Jul 11.

DOI:10.5114/aoms.2011.23407

PMID:22295024

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3258738/

Abstract

INTRODUCTION

The study was designed to clarify the role of (123)I-β-methyl-iodophenylpentadecanoic acid ((123)I-BMIPP) in the evaluation of myocardial fatty acid metabolism in patients with stable angina pectoris (AP) before and after percutaneous coronary intervention (PCI).

MATERIAL AND METHODS

TEN CONTROLS (MEAN AGE: 70.4 ±10.5 years) and 12 patients with AP (mean age: 67.4 ±11.6 years) and single vessel coronary artery disease participated in the radionuclide cardiac study. Scintigraphic images were acquired at 30 min and at 4 h after (123)I-BMIPP injection to determine early and delayed BMIPP uptake, respectively. The heart-to-mediastinum (H/M) ratio and the washout rate (WR) were calculated from the planar images. All patients underwent scintigraphy one day before PCI and again 1 month after successful PCI.

RESULTS

NO SIGNIFICANT DIFFERENCES IN THE EARLY OR DELAYED H/M RATIOS WERE OBSERVED BETWEEN THE PATIENTS AND THE CONTROLS BEFORE PCI (EARLY: 2.70 ±0.36 vs. 2.73 ±0.57; delayed: 2.26 ±0.33 vs. 2.40 ±0.43; p > 0.2 for both). The early and delayed H/M ratios remained unchanged with the comparison with before PCI (early: 2.72 ±0.27, delayed: 2.23 ±0.22; p > 0.2 for both). The global WR before PCI was significantly higher in the patients than in the control group (36.7 ±9.3%, vs. 28.1 ±8.2%, p = 0.02). However, the WR after PCI did not significantly differ between the patients and the controls (34.3 ±7.8% vs. 28.1 ±8.2%, p = 0.1).

CONCLUSIONS

These data may suggest that the WR of (123)I-BMIPP determined from the planar images enhances the presence of myocardial ischaemia.

摘要

简介

本研究旨在阐明（123）I-β-甲基-碘代苯戊酸（（123）I-BMIPP）在经皮冠状动脉介入治疗（PCI）前后稳定型心绞痛（AP）患者心肌脂肪酸代谢评估中的作用。

材料和方法

10 名对照者（平均年龄：70.4 ±10.5 岁）和 12 名 AP 患者（平均年龄：67.4 ±11.6 岁）和单支血管性冠状动脉疾病患者参与了放射性核素心脏研究。在（123）I-BMIPP 注射后 30 分钟和 4 小时采集闪烁显像图像，以分别确定早期和延迟 BMIPP 摄取。从平面图像计算心脏与纵隔（H/M）比值和洗脱率（WR）。所有患者在 PCI 前一天和成功 PCI 后 1 个月进行闪烁显像。

结果

在 PCI 前，患者与对照组之间的早期或延迟 H/M 比值无显著差异（早期：2.70 ±0.36 与 2.73 ±0.57；延迟：2.26 ±0.33 与 2.40 ±0.43；p > 0.2 均）。与 PCI 前相比，早期和延迟 H/M 比值保持不变（早期：2.72 ±0.27，延迟：2.23 ±0.22；p > 0.2 均）。在 PCI 前，患者的整体 WR 明显高于对照组（36.7 ±9.3%，与 28.1 ±8.2%，p = 0.02）。然而，PCI 后患者和对照组之间的 WR 无显著差异（34.3 ±7.8%与 28.1 ±8.2%，p = 0.1）。