一种使用改良的 Danishefsky 二烯的氨基萘醌安莎霉素方法。

An approach to aminonaphthoquinone ansamycins using a modified Danishefsky diene.

机构信息

Department of Chemistry and Pharmacology, Ludwig-Maximilians-Universität München and Center for Integrated Protein Science, 81377 Munich, Germany.

出版信息

Org Lett. 2012 Feb 17;14(4):1070-3. doi: 10.1021/ol203437a. Epub 2012 Feb 1.

DOI:10.1021/ol203437a

PMID:22296114

Abstract

A robust and scalable synthesis of a novel, cyano-substituted Danishefsky-type diene and its use in the Diels-Alder reaction with various dienophiles is reported. The diene allows for the rapid construction of highly substituted aminonaphthoquinones that occur in numerous ansamycin antibiotics.

摘要

报告了一种新型氰基取代的 Danishefsky 型二烯的稳健且可扩展的合成方法，及其在与各种亲二烯体的 Diels-Alder 反应中的应用。该二烯允许快速构建在许多 ansamycin 抗生素中存在的高度取代的氨基萘醌。