Department of Pathology, Ninewells Hospital and Medical School, Dundee, Scotland, UK.
Histopathology. 2012 Apr;60(5):838-42. doi: 10.1111/j.1365-2559.2011.04148.x. Epub 2012 Feb 1.
Ovarian gynandroblastomas are rare tumours that, by definition, comprise a combination of components resembling both female, typically granulosa cell tumour (GCT), and male, typically Sertoli or Sertoli/Leydig cell tumour (ST/SLT), sex cord/stromal differentiation. The histogenesis of these tumours is unknown and, in view of the very strong association between the C134W (402 C>G) FOXL2 mutation and adult-type GCT, we analysed a series of gynandroblastomas for this mutation.
Both components of each lesion were isolated by laser capture microdissection and the C134W (402 C>G) FOXL2 mutation was analysed by polymerase chain reaction sequencing. No mutation was identified in either the GCT or ST/SLT component of six cases, three of which contained adult-type GCT.
This suggests that, despite their similar morphological appearances, the GCT-like component of gynandroblastoma has a different molecular basis from conventional adult-type GCT. This finding underscores a more general principle that morphological similarity does not necessarily indicate molecular identity.
卵巢雌雄同体性生殖细胞瘤是一种罕见的肿瘤，根据定义，它由同时类似于女性（典型为颗粒细胞瘤[GCT]）和男性（典型为支持细胞或支持细胞/间质细胞瘤[ST/SLT]）性索/间质分化的成分组成。这些肿瘤的组织发生尚不清楚，鉴于 C134W（402 C>G）FOXL2 突变与成人型 GCT 之间存在很强的相关性，我们分析了一系列雌雄同体性生殖细胞瘤是否存在该突变。
通过激光捕获显微切割分离每个病变的两个成分，并通过聚合酶链反应测序分析 C134W（402 C>G）FOXL2 突变。在 6 例中，有 3 例包含成人型 GCT，均未在 GCT 或 ST/SLT 成分中发现突变。
这表明，尽管外观相似，但雌雄同体性生殖细胞瘤的 GCT 样成分与传统的成人型 GCT 具有不同的分子基础。这一发现强调了一个更普遍的原则，即形态相似不一定表示分子同一性。
