Department of Obstetrics and Gynecology, Faculty of Medicine, Adnan Menderes University, Aydın, Turkey.
Gynecol Endocrinol. 2012 Aug;28(8):640-3. doi: 10.3109/09513590.2011.650771. Epub 2012 Feb 1.
Increased inflammatory response and cytokines are claimed to play a significant role in the etiology of preeclampsia. Interleukin-6 (IL-6) is a proinflammatory cytokine. Limited number of studies evaluating IL-6 levels in preeclamptic patients have produced conflicting results. Therefore, the present study sought to compare maternal and umbilical cord serum levels of IL-6 in early- and late-onset preeclamptic pregnancies as well as in normal pregnancies.
A total of 69 participants were enrolled in the study. The control group consisted of 24 participants with normal pregnancies. Preeclampsia group consisted of 45 participants. The preeclampsia group was further classified into the subgroups of early- and late-onset preeclampsia. Late-onset preeclampsia group consisted of 24 women whereas early-onset preeclampsia group consisted of 21 women. Serum and umbilical cord samples of IL-6 were compared.
There was no significant difference between maternal and umbilical cord serum IL-6 concentrations between the preeclampsia and control group. No significant difference was observed in maternal and umbilical cord serum IL-6 levels between early- and late-onset preeclampsia groups.
Our results do not support an increase in IL-6 levels in patients with early- and late-onset preeclampsia. The clinical relevance of our findings needs to be further investigated.
炎症反应和细胞因子增加被认为在子痫前期的发病机制中起重要作用。白细胞介素-6（IL-6）是一种促炎细胞因子。评估子痫前期患者 IL-6 水平的研究数量有限，结果相互矛盾。因此，本研究旨在比较早发型和晚发型子痫前期妊娠以及正常妊娠中母血和脐血 IL-6 水平。
共有 69 名参与者纳入研究。对照组由 24 名正常妊娠的参与者组成。子痫前期组由 45 名参与者组成。子痫前期组进一步分为早发型和晚发型子痫前期亚组。晚发型子痫前期组由 24 名妇女组成，而早发型子痫前期组由 21 名妇女组成。比较了血清和脐带血清 IL-6 样本。
子痫前期组和对照组母血和脐血 IL-6 浓度之间无显著差异。早发型和晚发型子痫前期组之间母血和脐血 IL-6 水平无显著差异。
我们的结果不支持早发型和晚发型子痫前期患者 IL-6 水平升高。需要进一步研究我们研究结果的临床意义。
