Lou Jiatao, Xue Jian, Lin Qiang
Department of Laboratory Medicine, Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.
Asian Pac J Cancer Prev. 2011;12(9):2349-52.
Lung cancer is a prevalent cancer with a high death rate. Underlying mechanisms have been found to be highly correlated with epigenetics, especially with DNA methylation. With methylation array and other regulation data, we constructed a TF-gene regulation network and a TF-pathway network. Through those networks, we identified lung cancer related genes that were found by previous studies, and supposed a number of new examples. Our work demonstrated the new potential methylation for lung cancer.
肺癌是一种常见且死亡率高的癌症。已发现其潜在机制与表观遗传学高度相关，尤其是与DNA甲基化相关。利用甲基化阵列和其他调控数据，我们构建了一个转录因子-基因调控网络和一个转录因子-信号通路网络。通过这些网络，我们鉴定出了先前研究中发现的肺癌相关基因，并推测了一些新的例子。我们的工作展示了肺癌新的潜在甲基化情况。
