肿瘤坏死因子受体超家族成员 11B 多态性与女性膝骨关节炎的关联。
Tumour necrosis factor receptor superfamily member 11B polymorphisms and association with knee osteoarthritis in women.
机构信息
Department of Anatomy, Veterinary School, University of Bristol, Bristol, UK.
出版信息
Int J Immunogenet. 2012 Jun;39(3):207-9. doi: 10.1111/j.1744-313X.2012.01083.x. Epub 2012 Feb 2.
Abstract
We examined single-nucleotide polymorphisms (SNPs) across the tumour necrosis factor receptor superfamily member 11B (TNFRSF11B) gene and knee OA. We identified alleles in a VNTR region in intron 3 that was observed exclusively in women OA cases (P = 0.007, Pc = 0.042). Our results reveal that a previously unreported association between a VNTR genotype in TNFRSF11B and knee OA in women.
摘要
我们研究了肿瘤坏死因子受体超家族成员 11B（TNFRSF11B）基因和膝骨关节炎（OA）的单核苷酸多态性（SNPs）。我们在 3 号内含子中的 VNTR 区域发现了仅在女性 OA 病例中观察到的等位基因（P = 0.007，Pc = 0.042）。我们的研究结果揭示了 TNFRSF11B 中的 VNTR 基因型与女性膝 OA 之间以前未报道的关联。
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