Serviço de Patologia Veterinária, Departamento de Clínica Veterinária, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista - UNESP, Botucatu, Brazil.
BMC Vet Res. 2012 Feb 1;8:13. doi: 10.1186/1746-6148-8-13.
Salivary mucocele is an accumulation of saliva in a single or multiloculated cavity lined by connective tissue that is contiguous to a salivary gland-duct complex and is the most common condition affecting the salivary glands in dogs. Occasionally, different types of metaplastic lesions, such as squamous and osseous metaplasia - which are rare lesions in animals - can be observed in association with salivary mucocele.
A right facial enlargement was suddenly observed in a 4-year-old non-spayed female Shih-Tzu dog. The lesion presented itself as a soft and fluctuant mass located in the right side of the face near to the neck. Histologically, the mass consisted of a cavitary formation without an epithelial lining. Additionally, microscopic examination revealed the presence of osteoid-producing cells which gave rise to areas of bone formation, probably induced by irritation due to the presence sialoliths. Such cells and bone formations were also present in the cavity wall, consequently leading us to classify the condition as a salivary mucocele with osseous metaplasia.
In the present case, the pathogenesis was probably associated with the presence of sialoliths, which can behave as etiological agents for the metaplastic lesion. The occurrence of osteoid metaplasia is a rare peculiar condition in the canine salivar y gland, and due to the rarity and lack of information about this specific disease, no clinical data can yet be associated with the development of salivary mucocele with osseous metaplasia in dogs.
唾液腺黏液囊肿是一种唾液在由结缔组织衬里的单个或多房腔中的积聚，与唾液腺-导管复合体连续，是最常见的影响犬唾液腺的疾病。偶尔，不同类型的化生病变，如鳞状和骨化生 - 这些是动物中罕见的病变 - 可以与唾液腺黏液囊肿相关观察到。
一只 4 岁未绝育的雌性西施犬突然出现右侧面部肿胀。病变表现为位于颈部附近右侧面部的柔软波动肿块。组织学上，肿块由无上皮衬里的腔形成。此外，显微镜检查显示存在产生骨样的细胞，这些细胞导致骨形成区域，可能是由于存在涎石引起的刺激。这些细胞和骨形成也存在于腔壁中，因此我们将其归类为伴有骨化生的唾液腺黏液囊肿。
在本病例中，发病机制可能与涎石的存在有关，涎石可能是化生病变的病因。骨样化生的发生是犬唾液腺中罕见的特殊情况，由于这种特定疾病的罕见性和缺乏信息，目前还无法将任何临床数据与犬伴有骨化生的唾液腺黏液囊肿的发展相关联。
