Centre for Reproductive Medicine, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
Reprod Biomed Online. 2012 Mar;24(3):272-80. doi: 10.1016/j.rbmo.2011.11.012. Epub 2011 Nov 30.
This randomized controlled trial analyses the ability to control the oocyte retrieval schedule of gonadotrophin-releasing hormone antagonist cycles through the administration of oestradiol valerate during the luteo-follicular transition period prior to the initiation of ovarian stimulation. Eighty-six women undergoing ovarian stimulation for IVF/intracytoplasmic sperm injection were enrolled in the study. The control group (n = 42) received a standard ovarian stimulation protocol. In the pretreatment group (n = 44), patients were administered oestradiol valerate at a daily dose of 2 · 2 mg from day 25 of the preceding cycle onwards, during 6–10 consecutive days, depending on the day of the week. The primary endpoint was the proportion of patients undergoing oocyte retrieval during a weekend day (i.e. Saturday or Sunday), which was significantly lower in the pretreatment group (1/37, 2.7%) compared with the control group (8/39, 20.5%; P value = 0.029). The clinical pregnancy rates per started cycle were similar in the pretreatment group (38.6%) compared with the control group (38.1%). Pretreatment with oestradiol valerate results in a significantly lower proportion of patients undergoing oocyte retrieval during a weekend day and can be a valuable tool for the organization of an assisted reproduction centre.
这项随机对照试验分析了在卵巢刺激前的黄体-卵泡过渡期通过给予戊酸雌二醇来控制 GnRH 拮抗剂周期中取卵时间的能力。86 名接受 IVF/胞浆内精子注射的卵巢刺激的妇女被纳入本研究。对照组（n = 42）接受标准的卵巢刺激方案。在预处理组（n = 44）中，患者从上个周期的第 25 天开始，每天给予戊酸雌二醇 2.2 mg，连续 6-10 天，具体取决于星期几。主要终点是在周末（即星期六或星期天）进行取卵的患者比例，预处理组（1/37，2.7%）明显低于对照组（8/39，20.5%；P 值=0.029）。预处理组的每起始周期的临床妊娠率与对照组相似（38.6%）。戊酸雌二醇预处理可显著降低周末进行取卵的患者比例，对于辅助生殖中心的组织安排是一种有价值的工具。
