Allergy Unit, Faculty of Medicine, Mansoura University, Pin Code: 35516, Box 50, Mansoura, Egypt.
Indian J Pediatr. 2012 Sep;79(9):1176-80. doi: 10.1007/s12098-012-0694-z.
To compare lung function in wheezy infants, with risk factors of asthma and with some immunological parameters which may be useful as predictors of subsequent asthma.
The data of 241 infants aged 5–36 mo, with recurrent wheeze (≥3 episodes of physician confirmed wheeze) prior to receiving inhaled corticosteroids or anti-leukotrine agents was retrospectively analyzed. They were subdivided into 2 subgroups; those with asthma risk factors (132 patients) and those without (109 patients) Also, 67 healthy, age and sex matched children without recurrent wheezes were taken as control group. Total serum IgE, eosinophilic percentage, tPTEF/tE (time to peak expiratory flow to total expiratory time), total respiratory system compliance (Crs) and resistance of the respiratory system (Rrs) was done for patients and control groups.
Wheezy infants had a significantly higher eosinophilic percentage and total serum IgE as well as a significantly lower pulmonary function parameters when compared to healthy controls. Wheezy infants with positive family history of asthma and those who had not been breast fed showed significant reduction in the mean values of tPTEF/tE and increased both eosinophilic percentage and total serum IgE. Crs was significantly decreased in wheezy infants with positive seasonal variations and those who had increased both eosinophilic percentage and total serum IgE. Rrs showed significant increase in wheezy infants with positive family history of atopy and those who had increased eosinophilic percentage and increased total serum IgE.
Lung function, eosinophilic percentage, total serum IgE and asthma risk factors could be used as predictors for ongoing wheeze in this subset of children.
比较有哮喘危险因素和某些免疫参数的喘息婴儿的肺功能，这些参数可能有助于预测随后的哮喘。
回顾性分析了 241 名年龄在 5-36 个月、在接受吸入皮质激素或抗白三烯药物之前有反复喘息（≥3 次医生确诊的喘息）的婴儿的数据。他们被分为 2 个亚组；有哮喘危险因素（132 例）和无哮喘危险因素（109 例）。此外，还选择了 67 名无反复喘息、年龄和性别匹配的健康儿童作为对照组。对患者和对照组进行总血清 IgE、嗜酸性粒细胞百分比、tPTEF/tE（呼气峰流速至总呼气时间）、总呼吸系统顺应性（Crs）和呼吸系统阻力（Rrs）。
与健康对照组相比，喘息婴儿的嗜酸性粒细胞百分比和总血清 IgE 显著升高，肺功能参数显著降低。有哮喘家族史和未母乳喂养的喘息婴儿 tPTEF/tE 的平均值显著降低，嗜酸性粒细胞百分比和总血清 IgE 均升高。有季节性变化和嗜酸性粒细胞百分比和总血清 IgE 均升高的喘息婴儿 Crs 显著降低。有特应性家族史和嗜酸性粒细胞百分比和总血清 IgE 升高的喘息婴儿 Rrs 显著升高。
肺功能、嗜酸性粒细胞百分比、总血清 IgE 和哮喘危险因素可作为该亚组持续喘息的预测指标。
