Perikleous Evanthia, Fouzas Sotirios, Karageorgiou Athina, Steiropoulos Paschalis, Nena Evangelia, Chatzimichael Athanasios, Tsalkidis Aggelos, Paraskakis Emmanouil
Department of Pediatrics, University General Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupoli 68100, Greece.
Department of Paediatrics, University Hospital of Patras, University of Patras, Patra 26504, Greece.
World J Clin Pediatr. 2021 Nov 9;10(6):168-176. doi: 10.5409/wjcp.v10.i6.168.
Tidal breathing flow-volume (TBFV) analysis provides important information about lung mechanics in infants.
To assess the effects of breastfeeding on the TBFV measurements of infants who recover from acute bronchiolitis.
In this cross-sectional study, TBFV analysis was performed in infants with bronchiolitis prior to hospital discharge. The ratio of time to peak expiratory flow to total expiratory time (tPEF/tE) at baseline and after the administration of 400 mcg salbutamol was evaluated.
A total of 56 infants (35 boys), aged 7.4 ± 2.8 mo, were included. Of them, 12.5% were exposed to tobacco smoke and 41.1% were breastfed less than 2 mo. There were no differences in baseline TBFV measurements between the breastfeeding groups; however, those who breastfed longer than 2 mo had a greater change in tPEF/tE after bronchodilation (12% ± 10.4% 0.9% ± 7.1%; < 0.001). Moreover, there was a clear dose-response relationship between tPEF/tE reversibility and duration of breastfeeding ( < 0.001). In multivariate regression analysis, infants who breastfed less (regression coefficient -0.335, = 0.010) or were exposed to cigarette smoke (regression coefficient 0.353, = 0.007) showed a greater change in tPEF/tE after bronchodilation, independent of sex, prematurity, and family history of asthma or atopy.
Infants who recover from bronchiolitis and have a shorter duration of breastfeeding or are exposed to cigarette smoke, have TBFV measurements indicative of obstructive lung disease.
潮气呼吸流速容量（TBFV）分析可为婴儿肺部力学提供重要信息。
评估母乳喂养对急性细支气管炎康复期婴儿TBFV测量结果的影响。
在这项横断面研究中，对细支气管炎婴儿在出院前进行TBFV分析。评估基线时以及给予400微克沙丁胺醇后呼气峰值流速时间与总呼气时间的比值（tPEF/tE）。
共纳入56例婴儿（35例男婴），年龄7.4±2.8个月。其中，12.5%暴露于烟草烟雾，41.1%母乳喂养时间少于2个月。母乳喂养组之间基线TBFV测量结果无差异；然而，母乳喂养超过2个月的婴儿在支气管扩张后tPEF/tE的变化更大（12%±10.4%对0.9%±7.1%；P<0.001）。此外，tPEF/tE可逆性与母乳喂养持续时间之间存在明显的剂量反应关系（P<0.001）。在多变量回归分析中，母乳喂养时间短（回归系数-0.335，P=0.010）或暴露于香烟烟雾（回归系数0.353，P=0.007）的婴儿在支气管扩张后tPEF/tE变化更大，独立于性别、早产以及哮喘或特应性家族史。
从细支气管炎康复的婴儿，若母乳喂养时间较短或暴露于香烟烟雾，其TBFV测量结果提示存在阻塞性肺疾病。
