Association of breastfeeding with tidal breathing analysis in infants with bronchiolitis.

BACKGROUND

Tidal breathing flow-volume (TBFV) analysis provides important information about lung mechanics in infants.

AIM

To assess the effects of breastfeeding on the TBFV measurements of infants who recover from acute bronchiolitis.

METHODS

In this cross-sectional study, TBFV analysis was performed in infants with bronchiolitis prior to hospital discharge. The ratio of time to peak expiratory flow to total expiratory time (tPEF/tE) at baseline and after the administration of 400 mcg salbutamol was evaluated.

RESULTS

A total of 56 infants (35 boys), aged 7.4 ± 2.8 mo, were included. Of them, 12.5% were exposed to tobacco smoke and 41.1% were breastfed less than 2 mo. There were no differences in baseline TBFV measurements between the breastfeeding groups; however, those who breastfed longer than 2 mo had a greater change in tPEF/tE after bronchodilation (12% ± 10.4% 0.9% ± 7.1%; < 0.001). Moreover, there was a clear dose-response relationship between tPEF/tE reversibility and duration of breastfeeding ( < 0.001). In multivariate regression analysis, infants who breastfed less (regression coefficient -0.335, = 0.010) or were exposed to cigarette smoke (regression coefficient 0.353, = 0.007) showed a greater change in tPEF/tE after bronchodilation, independent of sex, prematurity, and family history of asthma or atopy.

CONCLUSION

Infants who recover from bronchiolitis and have a shorter duration of breastfeeding or are exposed to cigarette smoke, have TBFV measurements indicative of obstructive lung disease.