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血清素能药物对大鼠延迟条件辨别任务的影响；5-羟色胺1A受体在工作记忆中的作用。

Serotonergic drug effects on a delayed conditional discrimination task in the rat; involvement of the 5-HT1A receptor in working memory.

作者信息

Herremans A H, Hijzen T H, Olivier B, Slangen J L

机构信息

Utrecht University, Rudolf Magnus Institute of Neuroscience, Faculty of Pharmacy, Department of Psychopharmacology, PO Box 80082, 3508 TB, Utrecht, The Netherlands.

出版信息

J Psychopharmacol. 1995 Jan;9(3):242-50. doi: 10.1177/026988119500900307.

DOI:10.1177/026988119500900307
PMID:22297764
Abstract

We investigated the effects of serotonergic drugs on working memory (WM) in a delayed conditional discrimination task. The 5-HT(1A) receptor full agonist flesinoxan (0.3-3.0 mg/kg) dose- and delay-dependently impaired performance, indicating a specific effect on WM. The 5-HT(1A) receptor partial agonist ipsapirone, the 5-HT( 1B/1D/2C) agonist TFMPP, the 5-HT(1A) antagonist NAN190 and the serotonin re-uptake inhibitor fluvoxamine dose-dependently impaired performance, in a delay-independent manner, indicating no specific effect on WM. The 5-HT( 2) receptor antagonist ketanserin and the 5-HT(3) receptor antagonist ondansetron did not affect performance. It is suggested that the role of central serotonin receptors in WM may be restricted to 5-HT(1A) receptors.

摘要

我们在延迟条件辨别任务中研究了血清素能药物对工作记忆（WM）的影响。5-HT(1A)受体完全激动剂氟司必林（0.3 - 3.0毫克/千克）对行为表现的损害呈现剂量和延迟依赖性，表明对工作记忆有特定影响。5-HT(1A)受体部分激动剂伊沙匹隆、5-HT(1B/1D/2C)激动剂TFMPP、5-HT(1A)拮抗剂NAN190以及血清素再摄取抑制剂氟伏沙明对行为表现的损害呈剂量依赖性，且与延迟无关，表明对工作记忆无特定影响。5-HT(2)受体拮抗剂酮色林和5-HT(3)受体拮抗剂昂丹司琼不影响行为表现。提示中枢血清素受体在工作记忆中的作用可能仅限于5-HT(1A)受体。

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