Mauriño Jorge, Cordero Luis, Ballesteros Javier
AstraZeneca Medical Department, Madrid, Spain.
Patient Prefer Adherence. 2012;6:83-5. doi: 10.2147/PPA.S28354. Epub 2012 Jan 23.
The desired outcome in schizophrenia treatment has evolved from symptom management to maximization of quality of life and functional recovery. The aim of this study was to assess the relationship between a specific well-being measure, the Subjective Well-being under Neuroleptic Scale - short version (SWN-K), and the SF-36 Health Survey as a generic quality of life measure.
A multicenter, cross-sectional study was conducted with clinically stable outpatients diagnosed with schizophrenia. Spearman's rank correlation was used to assess the associations between the SWN-K total score, its five subscales, and the SF-36 domains.
Ninety-seven patients were included in the study. The mean age was 35 years (standard deviation = 10) and 72% were male. All correlations among domains were positive and most were statistically significant. The bodily pain domain of the SF-36 presented the lower correlations with the SWN-K (rho range 0.10-0.25), whereas the other seven domains correlated significantly (rho range 0.49-0.60, all P < 0.001). The largest correlations were obtained between the SWN-K and the SF-36 domains of general health (rho = 0.53), mental health (rho = 0.60), and vitality (rho = 0.54).
The positive but nevertheless moderate correlations observed between a specific well-being instrument and a generic quality of life scale supports the inclusion of diagnosis-specific tools for outcome assessment of patients with schizophrenia.
精神分裂症治疗的预期结果已从症状管理发展到生活质量最大化和功能恢复。本研究的目的是评估一种特定的幸福感测量工具——简明抗精神病药治疗下主观幸福感量表(SWN-K)与作为一般生活质量测量工具的SF-36健康调查之间的关系。
对诊断为精神分裂症的临床稳定门诊患者进行了一项多中心横断面研究。采用Spearman等级相关性分析来评估SWN-K总分及其五个子量表与SF-36各领域之间的关联。
97例患者纳入研究。平均年龄为35岁(标准差 = 10),72%为男性。各领域之间的所有相关性均为正,且大多数具有统计学意义。SF-36的身体疼痛领域与SWN-K的相关性较低(rho范围为0.10 - 0.25),而其他七个领域相关性显著(rho范围为0.49 - 0.60,所有P < 0.001)。SWN-K与SF-36的总体健康领域(rho = 0.53)、心理健康领域(rho = 0.60)和活力领域(rho = 0.54)之间的相关性最大。
一种特定的幸福感工具与一种一般生活质量量表之间观察到的正相关但适度的相关性,支持纳入针对精神分裂症患者结局评估的诊断特异性工具。