Southern Illinois University School of Medicine, Springfield, IL, USA.
Ther Clin Risk Manag. 2012;8:1-6. doi: 10.2147/TCRM.S22579. Epub 2012 Jan 12.
Bipolar affective disorder is a disabling illness with substantial morbidity and many management challenges. Traditional mood stabilizers such as lithium, valproate, and carbamazepine are often inadequate in controlling symptoms both during the acute and maintenance phase of treatment. Aripiprazole is a second-generation antipsychotic with a unique mechanism of action. Evidence suggests that it is effective in acute manic and mixed states. There are limited data to suggest its efficacy as a maintenance agent. Future studies will be needed to better define the role of aripiprazole relative to other traditional pharmacologic agents.
双相情感障碍是一种使人丧失能力的疾病，发病率高，管理方面存在诸多挑战。在急性和维持治疗阶段，传统心境稳定剂如锂盐、丙戊酸盐和卡马西平往往无法充分控制症状。阿立哌唑是一种具有独特作用机制的第二代抗精神病药。有证据表明，它在急性躁狂和混合状态中有效。关于其作为维持治疗药物的疗效，数据有限。需要进一步研究来更好地确定阿立哌唑相对于其他传统药物的作用。
