Department of Urology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
BJU Int. 2010 Apr;105(8):1141-6. doi: 10.1111/j.1464-410x.2009.08969.x.
To determine the role of treatment-associated improvement in nocturia in health-related quality of life (HRQL) in patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia, and secondarily to confirm the role of nocturia in HRQL at baseline and to compare the effects of watchful waiting, transurethral microwave treatment (TUMT) and transurethral resection of the prostate (TURP) to those of α1-adrenoceptor antagonists (α-blockers) on nocturia.
We retrospectively analysed using multiple regression a large single-centre database of patients receiving routine care for treatment-associated alterations of symptoms and HRQL (assessed at baseline, 2611 men) and 6-12 months after initiation of treatment (1258 men).
Among the symptoms assessed using the International Prostate Symptom Score, nocturia (together with urgency and weak stream) had the strongest correlation with HRQL at baseline and after treatment. Watchful waiting, α-blockers, TUMT and TURP reduced nocturia episodes by a mean (sd) of 7 (53)%, 17 (40)%, 32 (47)% and 75 (23)%, respectively. The treatment-associated improvements in nocturia (together with those of weak stream) had the strongest association with those of HRQL.
We conclude that among all LUTS assessed in the IPSS, nocturia has one of the strongest associations with HRQL, and that treatment-associated improvements in nocturia contribute considerably to overall improvements in HRQL.
确定与良性前列腺增生症相关的下尿路症状（LUTS）患者的治疗相关夜尿症改善在健康相关生活质量（HRQL）中的作用，其次确认夜尿症在基线时对 HRQL 的作用，并比较观察等待、经尿道微波治疗（TUMT）和经尿道前列腺切除术（TURP）与α1-肾上腺素能受体拮抗剂（α-阻滞剂）对夜尿症的影响。
我们使用多变量回归分析了一个大型单中心数据库，该数据库包括接受常规治疗以改变症状和 HRQL（在基线时评估，共 2611 名男性）的患者，并在治疗开始后 6-12 个月（共 1258 名男性）对其进行了评估。
在使用国际前列腺症状评分评估的症状中，夜尿症（与尿急和尿流弱一起）与基线和治疗后 HRQL 相关性最强。观察等待、α-阻滞剂、TUMT 和 TURP 分别平均减少夜尿症发作 7（53）%、17（40）%、32（47）%和 75（23）%。夜尿症（与尿流弱一起）的治疗相关改善与 HRQL 的改善相关性最强。
我们得出结论，在 IPSS 评估的所有 LUTS 中，夜尿症与 HRQL 的相关性最强之一，而且夜尿症的治疗相关改善对整体 HRQL 的改善有很大贡献。
