Bottex C, Martin A, Fontanges R
Department of Microbiology, Army Healthservice Research Center, Lyons, France.
Immunopharmacol Immunotoxicol. 1990;12(2):311-25. doi: 10.3109/08923979009019675.
The action of diacetoxyscirpenol (DAS)--a mycotoxin that belongs to the family of trichothecenes--on the immune system of the mouse was investigated. Two experimental models were used: 1) bacterial infection with Salmonella typhimurium and 2) the PFC (plaque-forming cells) test on the splenic lymphocytes of the mouse. The results obtained showed that these were dependent on the chronological order of the administration of DAS. When the toxin was administered after a bacterial infection or antigenic stimulation, it was observed an increase in the mortality rate and a very significant decrease in the antibody response. By contrast, when this mycotoxin was administered before the bacterial infection or antigenic stimulation, the results obtained were close to those from the controls. The importance of the administration of an immunomodulator of bacterial origin OM-89 before the immunodepression with DAS was shown.
研究了属于单端孢霉烯族的霉菌毒素——二醋酸雪腐镰刀菌烯醇（DAS）对小鼠免疫系统的作用。使用了两种实验模型：1）鼠伤寒沙门氏菌细菌感染和2）对小鼠脾淋巴细胞进行的PFC（空斑形成细胞）试验。所获结果表明，这些结果取决于DAS给药的时间顺序。当毒素在细菌感染或抗原刺激后给药时，观察到死亡率增加，抗体反应非常显著地降低。相比之下，当这种霉菌毒素在细菌感染或抗原刺激之前给药时，所获结果与对照组接近。结果显示了在使用DAS导致免疫抑制之前给予细菌来源的免疫调节剂OM-89的重要性。
