Besir Fahri Halit, Yazgan Omer, Ozhan Hakan, Aydin Yusuf, Basar Cengiz, Aydin Mesut, Alemdar Recai, Bulur Serkan
Department of Radiology, Medical Faculty, Düzce University, Düzce, Turkey.
Acta Cardiol. 2011 Dec;66(6):759-64. doi: 10.1080/ac.66.6.2136960.
Carotid intima media thickness (CIMT) is a strong predictor of future vascular events. However, data for Turkish individuals are limited and the association between cardiometabolic risk factors and CIMT has not been studied before.Therefore, we sought to investigate the CIMT and cardiometabolic risk associates in a large cohort of Turkish adults.
The study was conducted on 2230 participants (1427 women, 803 men with a mean age of 49). The participants underwent a Doppler Ultrasound examination of CIMT. Mean CIMT was 0.61 +/- 0.19 mm. Age- and sex-adjusted partial correlation analysis revealed that only systolic blood pressure and smoking amount was significantly correlated with CIMT. Receiver operator characteristics (ROC) calculations showed that age had the best area under the curve (AUC = 0.84), smoking had the best sensitivity (86%) and diastolic blood pressure (> 88 mmHg) had the best specificity (74%) in predicting a person with thickened carotid intima media (> 0.8 mm). Independent predictors of thickened carotid intima media were hypertension [(odds ratio (OR) = 2.74; 95% confidence interval (CI) = 1.663-4.53; P value < or = 0.001)], systolic blood pressure [OR = 1.01; 95% CI = 1.002-1.022; P value = 0.022] and age [OR = 1.11; 95% CI = 1.079-1.136; P value < or = 0.001).
Age, systolic blood pressure and smoking amount (pack/year) were the only age- and sex-adjusted associates of CIMT. Age had the best AUC in ROC analysis predicting thickened carotid artery intima media. Hypertension, systolic blood pressure and age were independent predictors of high CIMT in Turkish adults.
颈动脉内膜中层厚度（CIMT）是未来血管事件的有力预测指标。然而，土耳其人群的数据有限，且此前尚未研究过心脏代谢危险因素与CIMT之间的关联。因此，我们试图在一大群土耳其成年人中调查CIMT与心脏代谢风险的相关性。
该研究对2230名参与者（1427名女性，803名男性，平均年龄49岁）进行。参与者接受了CIMT的多普勒超声检查。平均CIMT为0.61±0.19毫米。年龄和性别校正后的偏相关分析显示，只有收缩压和吸烟量与CIMT显著相关。受试者工作特征（ROC）计算表明，在预测颈动脉内膜中层增厚（>0.8毫米）的人群时，年龄的曲线下面积（AUC）最佳（AUC = 0.84），吸烟的敏感性最佳（86%），舒张压（>88 mmHg）的特异性最佳（74%）。颈动脉内膜中层增厚的独立预测因素为高血压[比值比（OR）= 2.74；95%置信区间（CI）= 1.663 - 4.53；P值≤0.001]、收缩压[OR = 1.01；95% CI = 1.002 - 1.022；P值 = 0.022]和年龄[OR = 1.11；95% CI = 1.079 - 1.136；P值≤0.001]。
年龄、收缩压和吸烟量（包/年）是仅有的经年龄和性别校正后与CIMT相关的因素。在ROC分析中，年龄在预测颈动脉内膜中层增厚方面的AUC最佳。高血压、收缩压和年龄是土耳其成年人CIMT升高的独立预测因素。
